Growth Hormone Releasing Peptides



What are Growth Hormone Releasing Peptides?

Growth Hormone Releasing Peptides (GHRP) are a chemical class of Growth Hormone (GH) secretagogues that act on the hypothalamus and the pituitary to release GH. They stimulate the increase of Growth Hormone levels in the body while commonly increasing the secretion of Ghrelin. About 30 years ago, GHRP-6 had been the first highly potent GHRP developed. From that discovery, GHRP-2, Ipamorelin, Hexarelin and other Growth Hormone Releasing Peptides followed in research as the most-studied Ghrelin mimetic peptides. GHRP can become desensitized after constant usage throughout the day. Both GHRP-6 and Ipamorelin do not sensitize as long as there is a minimum of 2 hour breaks in between doses. GHRP-2 at lower doses does not desensitize, however, at higher doses, it is possible that desensitization may happen. On the other hand, Hexarelin has show to desensitize regardless of the breaks in between doses and the dosage amounts. The difference among the different Growth Hormone Releasing Peptides are the side effects.

GHRP-6 (His-DTrp-Ala-Trp-DPhe-Lys-NH2)

GHRP-6 is a true human growth hormone (HGH) secretagogue, which stimulates the body’s secretion of growth hormone (GH). GHRP-6 tells the body to produce more HGH and IGF-1, which in turn promotes food intake. It is also an effective use in treating GH deficiency, along with obesity, cachexia, and eating disorders. It causes intense hunger and gastric motility. It can have a mild effect on cortisol (a stress hormone) and prolactin (a hormone which can diminish sex drive). It is considered a first generation GHRP.

GHRP-2 (DAla-D-2-Nal-Ala-Trp-DPhe-Lys-NH2)

GHRP-2 has a more intense GH release with no gastric motility and less hunger effect. GHRP-2 has shown to increase IGF-1 levels, and when used with Growth Hormone Releasing Hormone (GHRH), helps increase the natural secretion of HGH. It can have a stronger effect within the normal range on prolactin and cortisol. GHRP-2 can help with increased muscle gains, decreased fat mass and reverse aging effects. It is considered a second generation peptide.

Hexarelin (His-D-2-methyl-Trp-Ala-Trp-DPhe-Lys-NH2)

Hexarelin is the strongest of all of the GHRPs in causing an increase in GH release, however it has the strongest potential to increase cortisol & prolactin in the higher levels of normalcy. Hexarelin can be added to other GHRP’s (such as Ipamorelin & GHRP-2) in lower dosages, to help elevate GH without incurring the desensitization that is common when using Hexarelin alone. It can help increase strength, promote fat reduction and help with healing injuries.

Ipamorelin (Aib-His-D-2-Nal-DPhe-Lys-NH2)

Ipamorelin does not release as much GH compared to the other Growth Hormone Releasing Peptides, however it causes virtually no hunger or gastric motility. Most importantly, it does not increase cortisol or prolactin; it is specifically meant for GH release. Ipamorelin is beneficial for fat loss and helping repair injuries. It is considered a third generation peptide.

Growth Hormone Releasing Peptides vs Growth Hormone Releasing Hormones

Hexarelin, Ipamorelin, GHRP-6 and GHRP-2 belong to a class of Growth Hormone secretagogues known as Ghrelin mimetic or GHRP. Compared to Growth Hormone Releasing Hormones (such as Sermorelin, Modified GRF 1-29, and CJC-1295), which are a separate class of growth hormone secretagogues, Ghrelin mimetic primarily increase GH release in the somatotrophs within the pituitary. Studies have shown that Ghrelin mimetics have shown that they release more GHRH compared to GHRH. On the other hand, GHRH slightly increases somatotrophin output as more somatotrophs help stimulate the release growth hormone. Also, GHRH is often used along with GHRP because when GHRH is used alone, it will only be effective when somatostatin is low. GHRP can however be used alone because it is able to create a larger pulse of growth hormone on its own.

Growth Hormone Releasing Peptides