BPC-157, TB-500 10mg (Blend)

115.00 USD

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$115.00
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BPC157 5mg, TB-500 5mg (10mg Total Blend)

BPC-157, TB-500 10mg (Blend)

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Product Usage: THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabled as a drug, food or cosmetic.

Potential BPC-157 and TB-500 Synergy in Wound Repair

Research reveals that BPC-157 and TB-500, which both help to stimulate wound healing via different biochemical pathways, may have synergistic effects when combined together.

Cell Migration

Successful wound healing depends on fibroblasts, which regulate extracellular matrix production, as well as cells of the immune system. For these cells to do their jobs, they need to move to the location of injury. This movement, called migration, is heavily dependent the protein actin. Both BPC-157 and TB-500 are important in actin regulation. BPC-157 works at the level of the gene to increase actin production[1]. TB-500, an actin binding protein, helps to sequester actin in areas where it is most useful for building filaments from actin to allow for cell movement[2]. Together, BPC-157 and TB-500 work synergistically to increase the quantity and function of actin and thus increase the rate at which fibroblasts and cells of the immune system migrate to areas of injury.

The Big Picture Involves Growth Hormone

Both TB-500 and BPC-157 interact with growth hormone in the healing process. BPC-157 increases the expression of growth hormone receptors on fibroblasts, boosting the longevity of these cells and thus their ability to promote soft tissue regeneration[3]. With TB-500 on board, the extra growth hormone receptors will not go to waste because the fibroblasts will have adequate stores of actin to make use of their elongated lifespans. Combining TB5-00, BPC-157, collagen, and a growth hormone secretagogue is a surefire way to increase rates of wound healing and may one day replace standard treatment regimens as the gold standard.

Resources

  • [1] C.-H. Chang, W.-C. Tsai, M.-S. Lin, Y.-H. Hsu, and J.-H. S. Pang, “The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration,” J. Appl. Physiol., vol. 110, no. 3, pp. 774–780, Oct. [Physiology.org]
  • [2] J. Kim and Y. Jung, “Potential Role of Thymosin Beta 4 in Liver Fibrosis,” Int. J. Mol. Sci., vol. 16, no. 5, pp. 10624–10635, May 2015. [NCBI]
  • [3] C.-H. Chang, W.-C. Tsai, Y.-H. Hsu, and J.-H. S. Pang, “Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts,” Mol. Basel Switz., vol. 19, no. 11, pp. 19066–19077, Nov. 2014. [NCBI]