BPC-157 5mg

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BPC-157

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BPC-157 

 

BPC 157 (Body Protection Compound-157) is a pentadecapeptide made up of 15 amino acids. The amino acids sequence in BPC 157 is similar to a portion of the human BPC amino acid sequence. Human BPC is found in the gastric juice. Experiments have shown that BPC 157 enhances the healing of wounds, including tendons wounds such as transected Achilles tendons of rats. The aim of this study was to investigate the probable mechanism that BPC 157 utilizes to accelerate the healing process in an injured tendon. The study used two group of tendon explants of which one group was cultured in a BPC 157-containing medium while the other group was cultured in a medium lacking BPC 157. These cultures were thereafter examined for tendon fibroblasts outgrowths. Such outgrowths indicated tendon regeneration.The results revealed that the explants’ outgrowth was significantly accelerated in the culture containing BPC 157 as compared to the culture lacking BPC 157. Also, a MTT assay did show that BPC 157 does not directly affect cellular proliferation in a culture of rat-derived Achilles tendon. However, results also showed that BPC 157 significantly increased the survival of cells under oxidative stress. Furthermore, the Transwell filter migration assay showed that BPC 157 significantly increased in-vitro fibroblast migration in a dose-dependent fashion. Moreover, BPC 157 accelerated the dispersal of the fibroblasts in culture dishes in a dose-dependent manner.

 

Additionally, FITC-phalloidin staining was able to demonstrate that BPC 157 induces F-actin formation in fibroblasts. Likewise, Western blot analysis was able to detect the production and activation of paxillin and FAK proteins. The western blot analysis also showed that BPC 157 increases the extent of phosphorylation of paxillin and FAK proteins without affecting the amounts produced.

 

Thus, it can be concluded that BPC 157 enhances the ex-vivo growth and in-vitro cellular migration of fibroblasts derived from rat tendon explants. Moreover, BPC 157 also increases the probability of a cell surviving under oxidative stress. These actions of BPC 157 are probably mediated by the activation (through phosphorylation) of the proteinic FAK-paxillin pathway.  

 

BPC-157 Peptide

BPC-157

Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val.

 Molecular FormulaC62H98N16O22

 Molecular Weight: 1419.556 g/mol

 PubChem CID: 108101

 InChI KeyHEEWEZGQMLZMFE-DGQLYNSISA-N

Chemical Names: Bpc 15; Bpc 157; Booly protection compound 15; Bpc-157; BPC-15; UNII-8ED8NXK95P 

 

BPC-157: Wound Healing and Immune Function

 

BPC-157 is a partial form of the protein body protection compound (BPC). BPC is a natural component of human stomach secretion where it is thought to protect the lining of the GI tract from the corrosive effects of stomach acid. BPC-157 has been found to promote healing not just in the GI tract, but throughout the body. It has also recently been found to promote blood vessel growth, affect serotonin synthesis, and play a role in alcohol metabolism.

 

BPC-157 and Healing

 

BPC-157 has been shown to promote healing in a number of conditions ranging from inflammatory bowel disease the tendon and muscle damage1. Studies in rodents reveal that the healing response results, at least partially, from the fact that BPC-157 causes an up regulation of growth hormone receptors in injured tissues2. In other words, BPC-157 helps to recruit growth hormone to the area of injury by increasing the number of receptors for the hormone.

 

Other studies show that BPC-157 can boost the function of fibroblasts that are primarily responsible for laying down the foundation of connective tissues like skin, cartilage, muscle, tendon, and bone. In studies of rats, achilles tendon trance sections heal faster and more completely when BPC-157 is applied directly to the wound3. Not only does BPC-157 increase the number of growth hormone receptors in these tissues to promote healing, it also increases numbers of healing cells like mononuclear cells, granulocytes, and fibroblasts. Research indicates that BPC-157 protects the cells from death, and allows them to survive in harsh conditions for longer periods of time.4

 

BPC-157 and Blood Vessel Growth

 

BPC-157 contributes to the growth of new blood vessels, but the underlying mechanism remains unclear. A recent study using chick chorioallantoic membrane has revealed that BPC-157 alters the expression of VEGFR2, a well-known peptide in the process of blood vessel formation. Not only does BPC-157 increase the expression of VEGFR2, it appears to promote movement of this peptide to areas where it is most active5.

 

BPC-157 and Serotonin

 

Serotonin is a well-known central nervous system signaling molecule often indicated as at least one of the culprits responsible for depression. Preliminary research in rats suggests that BPC-157 alters the expression of serotonin in various regions of the brain. For instance, BPC-157 reduces the synthesis of serotonin in the hippocampus and hypothalamus. On the other hand, BPC-157 appears to have no effect on the synthesis of serotonin in other regions of the brain. It is not clear what causes this effect or what the long-term consequences of the dark6. However, it has increased interest in BPC-157 as a potential way of probing the brain’s serotonin system.

 

BPC-157 and Alcohol

 

The effects of BPC-157 on alcohol intoxication are quite interesting. Studies in rats suggest that the peptide can actually counteract some of the acute aspects of intoxication. In fact, research suggests that BPC-157 can counteract not only of the effects of acute intoxication, but also the effects of withdrawal. This is critical, because alcohol withdrawal can be life-threatening. This research suggests that BPC-157 can protect reflexes, reduce seizures, and even lower mortality rates when dealing with acute intoxication and alcohol withdrawal7.

 

Resources

 

1.            Cerovecki, T. et al. Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat. J. Orthop. Res. Off. Publ. Orthop. Res. Soc. 28, 1155–1161 (2010).

2.            Chang, C.-H., Tsai, W.-C., Hsu, Y.-H. & Pang, J.-H. S. Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Mol. Basel Switz. 19, 19066–19077 (2014).

3.            Staresinic, M. et al. Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth. J. Orthop. Res. Off. Publ. Orthop. Res. Soc. 21, 976–983 (2003).

4.            Chang, C.-H., Tsai, W.-C., Lin, M.-S., Hsu, Y.-H. & Pang, J.-H. S. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J. Appl. Physiol. Bethesda Md 1985 110, 774–780 (2011).

5.            Hsieh, M.-J. et al. Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. J. Mol. Med. Berl. Ger. 95, 323–333 (2017).

6.            Tohyama, Y., Sikirić, P. & Diksic, M. Effects of pentadecapeptide BPC157 on regional serotonin synthesis in the rat brain: alpha-methyl-L-tryptophan autoradiographic measurements. Life Sci. 76, 345–357 (2004).

7.            Boban-Blagaic, A. et al. The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice. The effect of N(G)-nitro-L-arginine methyl ester and L-arginine. Med. Sci. Monit. Int. Med. J. Exp. Clin. Res. 12, BR36-45 (2006).