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The Research Effects of TB-500 on Tissue Growth

“product By Logan 4 years ago

TB-500 is also known as thymosin beta 4 (TB4). Thymosin Beta 4 has been found, in animal models, to play a central role in controlling the structure of cells. By improving cell structure, TB-500 is thought to aid in wound healing, improve cell responses to stress, and even help cells to live longer. Scientific animal research studies have shown that TB-500's role in regulating cell structure may eventually make it a leading therapeutic in wound healing, blood vessel repair, and even ocular (eye) repair.

The Basics

TB-500 is a regulator of actin polymerization and actin is one of the basic structural components of the cell membrane. Unlike the structural components of a building, actin is an active structural component, which is to say that actin filaments are constantly being built and broken down. In fact, the assembly and disassembly of actin filaments is one of the primary means by which cells are able to move.

TB-500 binds to actin and acts to control levels of actin monomers within the cell. Release of these monomers from TB-500 drives actin polymerization and thereby affects both the structure of the cell membrane as well as cell motility [1]. Increased levels of TB4 are observed in wound healing in animal models and supplementation with TB-500 has been shown to promote tissue recovery after exercise in rat models.

Why TB-500 Matters

Blood vessels are a necessary prerequisite for all biochemical processes from cell growth to tissue repair and remodeling. TB-500 has been shown to encourage migration of endothelial (vascular) cells in animal and in vitro models. By encouraging migration, TB-500 can promote blood vessel growth in animal models, even in tissues like cartilage [2].

By encouraging cell growth, TB-500 not only aids in tissue repair, but helps to ensure more thorough and complete repair. A study in mouse models of heart attack found that TB-500 initiates capillary tube formation, encouraging the heart muscle to regenerate and inhibiting death in heart cells after injury [3]. In short, TB-500 can both protect cells from damage and encourage repair following damage.

The Big Picture

TB-500 has effects in a wide range of tissues such as vascular, cardiac muscle, corneal, skin, and skeletal muscle tissues. Research in animal models has been promising, suggesting that TB-500 may be a useful tool not just to speed wound healing and recovery from injury, but also to ensure that injuries are more limited and that repairs are more complete.


[1] M. C. Sanders, A. L. Goldstein, and Y. L. Wang, "Thymosin beta 4 (Fx peptide) is a potent regulator of actin polymerization in living cells.," Proc. Natl. Acad. Sci. U. S. A., vol. 89, no. 10, pp. 4678-4682, May 1992.

[2] K. M. Malinda, A. L. Goldstein, and H. K. Kleinman, "Thymosin beta 4 stimulates directional migration of human umbilical vein endothelial cells.," FASEB J., vol. 11, no. 6, pp. 474-481, May 1997.

[3] "Thymosin Beta-4 Molecule Prompts Damaged Cells To Repair Themselves After Heart Attack," Science 2.0, 27-Aug-2014. [Online]. Available: http://www.science20.com/news_releases/thymosin_beta4_molecule_prompts_damaged_cells_repair_themselves_after_heart_attack. [Accessed: 02-Dec-2015].