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Thymosin Beta 4 (TB-500) and the Brain

“product By Logan 6 months ago

Research has shown that when it comes to brain health, there are few drugs, supplements, or diets that make much difference. Unfortunately, the brain has remained a mystery to medical science and thus efforts to determine how to keep the brain healthy have been hindered. Science can tell us only that regular exercise and a relatively meat-free diet are associated with long-term brain health. There may, however, be some new evidence regarding thymosin beta 4 (also known as TB-4, or TB-500) and its impact on neural health.

Thymosin Beta 4

TB-500 (TB-4) is a naturally occurring peptide that is known to produce a vast array of healing and regenerative effects. It appears to promote everything from bone remodeling and growth after fracture to healing of heart muscle after a myocardial infarction (heart attack). Recent research in rats now suggests that TB-500 (TB-4) may improve neurological outcomes after stroke or brain damage.

Neurologic Restoration

Treatment of neurological diseases is still in the Stone Age, for the most part. Advanced drugs, like tissue plasminogen activator (designed to dissolve clots), only produce benefit in about 30% of subjects. Restorative therapies, which are designed to remodel the nervous system so that existing structures can take over some of the lost function, have been difficult to develop[1].

Studies in rats indicate that TB-500 (TB-4) promotes remodeling in both the central nervous system (CNS) and peripheral nervous system (PNS). TB-500 (TB-4) is found in all mammalian cells and seems to control a very complicated process by which certain cells become more responsive to injury. In the nervous system, TB-500 (TB-4) has been observed to activate oligodendrocytes, the cells that support neurons and keep them healthy[2]. Rats suffering from stroke show improved blood vessel and neural growth in the brain regions surrounding the damaged area, with concomitant improvements in behavioral, motor, and cognitive indices[3].

Disease Prevention

It isn't yet clear if TB-500 (Thymosin Beta 4) has preventative effects in addition to its restorative effects. In fact, exogenous administration of the peptide to subjects suffering brain injury has not yet been attempted. The science surrounding this peptide is in its infancy, but the results to date are promising. There is a great deal of hope, among neuroscientists and physicians, that TB-4 may be useful in staving off the effects of aging and dementia.


[1] D. C. Morris, Y. Cui, W. L. Cheung, M. Lu, L. Zhang, Z. G. Zhang, and M. Chopp, "A dose-response study of thymosin β4 for the treatment of acute stroke," J. Neurol. Sci., vol. 345, no. 1-2, pp. 61-67, Oct. 2014.

[2] P. Cheng, F. Kuang, H. Zhang, G. Ju, and J. Wang, "Beneficial effects of thymosin β4 on spinal cord injury in the rat," Neuropharmacology, vol. 85, pp. 408-416, Oct. 2014.

[3] M. Chopp and Z. G. Zhang, "Thymosin β4 as a restorative/regenerative therapy for neurological injury and neurodegenerative diseases," Expert Opin. Biol. Ther., vol. 15, no. sup1, pp. 9-12, Jun. 2015.