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Peptide Sciences Blog

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Thymalin boosts immune system while mitigating fever and excess cell death induced by cytokine storms.

By Nemo 3 months ago

Immune Paralysis Following "cytokine storm" may be reversed by Thymalin.

"Uncontrolled development of the initial [cytokine storm] stage inevitably leads to immune imbalance, which increases the probability of secondary infections, such as pneumonia, and activation of latent herpes virus (including cytomegalovirus) infections." (2)

"Over the last decade, preclinical and clinical studies have definitively shown that sepsis leads not only to hyperinflammation, but also impaired immunity, including dysfunction of the adaptive immune system. Certain investigators and clinical practitioners believe that the main cause of the failure of sepsis therapy involves the development of severe immunodeficiency..." (2)

“Administration of Thymalin to old mice led to an increase of the titer of FTS in the blood, the restoration of disturbed circannual rhythm, the number of CD4+ cells in the bone marrow, and the concentration of corticosterone in the blood.” (4) “Both natural and synthetic pharmaceuticals activated T-cell differentiation, T-cell recognition of peptide-MHC complexes, induced the changes in intracellular composition of cyclic nucleotides and cytokine [interleukin (IL-2), interferon (IFN)] excretion of blood lymphocytes.” (3)

"Adequate zinc is essential for T-cell division, maturation, and differentiation. Zinc itself is a cofactor for thymulin, a best known zinc-dependent thymic hormone crucial for T-cell formation and maturation which exists in two forms, a zinc-bound active one, and a zinc-free inactive form. What’s more, zinc may also prevent the programmed death (apoptosis) of precursor T-cell populations and mature CD4+T cells through various enzymatic mechanisms and through chronic production of glucocorticoids. Thymulin and thymopentin restore antibody avidity in aged or thymectomized animals, enhance antibody production in aging mice... Additionally, thymulin reduces induced hyperalgesia in rats and mice.” (7)


Thymulin: An Emerging Anti-Inflammatory Molecule