Peptide Sciences Blog

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How can Thymosin Beta4 (TB500) improve recovery, inflammation, neuropathies, fibrosis, telomerase and senescent cell removal?

By Nemo 3 months ago

Thymosin B4 Reduces Inflammation by Upregulating MicroRNA-146a and Promotes Myelin

"Tissue inflammation results from neurological injury, and regulation of the inflammatory response is vital for neurological recovery. The innate immune response system, which includes the Toll-like receptor (TLR) proinflammatory signaling pathway, regulates tissue injury... TB4-mediated oligodendrogenesis results from [up-regulating] miR-146a [causing the] suppression [of] the TLR proinflammatory pathway and modulation of the p38 MAPK pathway." (8)

"By targeting IRAK1 and TRAF6, miR-146 inhibits NF-κB activation. We therefore hypothesized that TB4 regulates the TLR proinflammatory signaling pathway by specifically regulating miR-146a to promote differentiation of OPCs [oligodendrocyte progenitor cells] to mature myelin basic protein (MBP)-expressing OLs [oligodendrocytes]... transfection with anti-miR-146a inhibitor nucleotides significantly inhibited the expression of MBP and phosphorylation of p38 MAPK." (8)

The Research Effects of TB-500 on Tissue Growth

By Logan 8 months ago

TB-500 is also known as thymosin beta 4 (TB4). Thymosin Beta 4 has been found, in animal models, to play a central role in controlling the structure of cells. By improving cell structure, TB-500 is thought to aid in wound healing, improve cell responses to stress, and even help cells to live longer. Scientific animal research studies have shown that TB-500's role in regulating cell structure may eventually make it a leading therapeutic in wound healing, blood vessel repair, and even ocular (eye) repair.

TB-500 (Thymosin Beta-4) Peptide Research

By Michael 8 months ago

TB-500 also known as Thymosin Beta 4 is a naturally occurring peptide. It is found in high concentrations in blood platelets, wound fluid and other tissues in the body. TB-500 is not a growth factor; rather, it is a major actin regulating peptide. TB-500 (Thymosin Beta 4) has been found to play an important role in protection, regeneration and remodeling of injured or damaged tissues. The gene for TB-500 (Thymosin Beta 4) has also been found to be one of the first to be upregulated after a wound occurs.

Thymosin Beta 4 (TB-500) and the Brain

By Logan 8 months ago

Research has shown that when it comes to brain health, there are few drugs, supplements, or diets that make much difference. Unfortunately, the brain has remained a mystery to medical science and thus efforts to determine how to keep the brain healthy have been hindered. Science can tell us only that regular exercise and a relatively meat-free diet are associated with long-term brain health. There may, however, be some new evidence regarding thymosin beta 4 (also known as TB-4, or TB-500) and its impact on neural health.

Thymosin Beta 4

TB-500 (TB-4) is a naturally occurring peptide that is known to produce a vast array of healing and regenerative effects. It appears to promote everything from bone remodeling and growth after fracture to healing of heart muscle after a myocardial infarction (heart attack). Recent research in rats now suggests that TB-500 (TB-4) may improve neurological outcomes after stroke or brain damage.