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Peptide Sciences Blog

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MT-2 (Melanotan-2) and Hunger

By Logan 4 years ago

It is has been known for some time that leptin regulates satiety, but the exact mechanism of regulation has remained elusive. Research has recently revealed that leptin and melanocortins affect the same brain regions associated with hunger and metabolism. This finding has led to new insights into both leptin physiology and the effects of melanocortin analogues like melanotan-2 (MT-2).

The Role of Leptin in Hunger

Leptin, which is made by fat cells, controls both food intake and energy expenditure. A large majority of its effects are mediated through proopiomelanocortin (POMC) neurons in the central nervous system. By stimulating POMC neurons, leptin creates feelings of fullness. In some individuals, a decreased sensitivity of POMC neurons to leptin has been linked to an inability to detect satiety[1].

Melanotan II Facts and Myths

By Jonathan 6 years ago

Melanotan II is a synthetic cyclic lactam analog of naturally occurring α-MSH (melanocyte-stimulating hormone) developed by the University of Arizona and is known to have skin darkening effects as a result of increased production of skin darkening pigments. In clinical trials, Melanotan II has also been found to have aphrodisiac effects.

What is Melanotan 2?

By Michael 6 years ago

Melanotan 2 also known as Melanotan II, is a synthetically produced variant of a peptide hormone naturally produced in the body that stimulates melanogenesis, a process responsible for pigmentation of the skin. This peptide hormone, called alpha-Melanocyte stimulating hormone or MSH, activates certain melanocortin receptors in the process of exerting its effects. Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido via these melanocortin receptors. As a result, Melanotan 2 has been shown in studies to exhibit appetite suppressant, lipolytic, and libido-enhancing effects in addition to promoting skin tanning. Melanotan 2 has been researched extensively for use in protecting against the harmful effects of ultraviolet radiation from sunlight due to Melanotan 2's melanogenesis-stimulating properties. Additionally, Melanotan 2 has been studied at length as a potential remedy for the treatment of sexual dysfunction.