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Peptide Sciences Blog

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IGF1 LR3 Information

By Carl 6 years ago

IGF1 LR3 (insulin-like growth factor-1 Long R3) is a non-glycosylated, recombinant polypeptide chain made up of 83 amino acids. IGF1 LR3 is the recombinant form of human IGF-1, and as such it contains the entire native amino acid sequence but with two major modifications: substitution of arginine (abbreviated R or arg) at position 3 with glutamic acid (abbreviated E or Glu) hence the label R3; and the extension of the N-terminus of the native sequence by a 13 amino-acid peptide hence the label long. The native form of a polypeptide refers to the naturally occurring amino acid sequence and the resultant conformational structure. The molecular weight of IGF1 LR3 as measured by Mass Spectrometry is 9.116 kD (kiloDaltons). A specifically designed protein expression system is utilized in the production of IGF1 LR3 in Escherichia Coli. Thereafter, chromatographic techniques are used to correctly fold and purify the IGF1 LR3 to the highly-active and functional IGF1 LR3 that can bind to human IGF-1R (insulin-like growth factor-1 receptor).

The Research Effects of IGF-1 LR3

By Michael 7 years ago

It is widely acknowledged that IGF1 LR3 is a powerful stimulator of muscle growth. Still, many are unaware of how IGF-1 LR3 exerts this effect on muscle tissue. While IGF-1 LR3 supports the growth and retention of existing muscle tissue, it also promotes the growth of new muscle cells and fibers. The ability of IGF-1 LR3 to additionally stimulate muscle cell proliferation underlies its potent anabolic nature and differentiates it from other muscle-building agents.

IGF-1 Levels and the Aging Process

By Michael 7 years ago

Multiple studies have confirmed that declining levels of IGF-1 play a key role in the negative effects associated with the aging process, including a decrease in lean muscle mass and an increase in adipose (fat) tissue. One particular study conducted on 21 healthy men aged 61 to 81 years only provides further support for the notion that low IGF-1 levels in the body are strongly correlated with an increase in aging’s adverse effects.