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Peptide Sciences Blog

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Hexarelin research and the reduction of cardiac fibrosis

By Nemo 3 months ago

"MMPs, particularly MMP-9 and MMP-2 [collagen degrading enzymes], are involved in cardiac fibrosis. Activities of MMP-2 and MMP-9 in the heart did not show significant differences between SHRs and Wistar rats (Fig. 6). However, hexarelin treatment remarkably increased MMP-2 and MMP-9 activities in SHRs, especially MMP-9 activity, in a GHS-R-dependent manner, since blockade of GHS-R abolished the hexarelin-induced increase in MMP-2 and MMP-9 activities (Fig. 6A). mRNA expression of TIMP-1, the inhibitor of MMPs, was dramatically increased in SHRs compared with Wistar rats and was reduced by hexarelin in SHRs in a GHS-R-dependent manner (Fig. 6B)."

Hexarelin suppressed TIMP-1 mRNA and its inhibition of collagen degrading enzymes in the rat heart, thereby boosting the collagen degrading enzymes MMP-2 and MMP-9.

Hexarelin protects heart cells from hypertrophy by stimulating autophagy.

By Nemo 3 months ago

“Ang-II induced cardiomyocyte hypertrophy, oxidative stress, apoptosis and decreased cell survival, all of which were significantly suppressed by hexarelin (a growth hormone peptide) treatment which also enhanced autophagy in hypertrophic H9C2 cells.”‬