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How does BPC-157 help balance dopamine, cardiovascular function, and healing?

By Nemo 2 months ago

Multi-Organ Membrane Repair and Dopamine Balancing.

"Pentadecapeptide BPC 157 antagonises the incidence of a series of gastrointestinal lesions, it has a positive impact on the healing processes of various wounds, a proven angiogenic effect, protective effect on endothelium and it modulates synthesis of NO." (1)

"Apart from the effects on various gastrointestinal lesions, the potentially beneficial effect on pancreas, liver injuries, endothelium and heart damage, i.e. dysrhythmias following reoxygenation, and blood pressure, along with effect on experimental acute/chronic inflammation, wound and fracture (pseudoarthrosis) healing are described. It appears that these beneficial effects all together provide a particular network reflecting activity of a special peptidergic defence system." (4)

"In support of this concept, it appears that there are interactions of this pentadecapeptide with many important systems (namely, dopamine-, NO-, prostaglandin-, somatosensory neurone-systems), that could provide a basis for the observed protective effects. Moreover, since disturbance of these systems' functions (i.e. dopamine-, NO-, somatosensory neuronal-system) which manifest either over-activity or as inhibition, may contribute to the multiple lesions in different organs. The reported evidence that this pentadecapeptide is able to counteract both their over-action, and their inhibition, may suggest this pentadecapeptide as a new, but most probably essential physiological defence system and that should be further investigated." (4)

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BPC157 and Healing

By Logan 6 months ago

BPC-157 and Healing

BPC 157 is a part of a naturally occurring protein known as body protection compound (BPC). BPC was first isolated from gastric (stomach) juice, but has also been found in other locations, such as the skin and liver. Previous research in animal test subjects has indicated that BPC 157 and BPC both promote healing. New animal research is starting to shed some light on just how they do that.

Fibroblast Outgrowth and Migration

Fibroblasts are motile (move about) cells found in most connective tissue (bones, tendons, muscle, gastric mucosa, skin, etc.). When damage to tissue occurs, fibroblasts migrate to the site of injury in order to begin the process of repair. They also divide and reproduce (outgrowth) to increase the number of fibroblasts available for tissue repair.

In in vitro studies reveal that migration of fibroblasts is directly affected by BPC 157 concentrations. Where BPC 157 levels are the highest, more fibroblasts can be found.

Evidence shows that BPC 157 is not just an attractant, but that it causes fibroblasts to migrate nearly 2.5 times faster than normal. Not only do the cells migrate in response to BPC 157 levels, they reproduce in response to them as well. Fibroblast outgrowth is approximately three times higher in the presence of BPC 157 [1].

Cell Survival and BPC 157

In vitro experiments indicate that fibroblasts survive for longer in the presence of BPC 157. Fibroblasts survive about 1.5 times longer when BPC 157 is present [2]. What is more, those cells tend to be healthier and more active and thus more capable of carrying out their repair roles.

The Net Effect

By encouraging fibroblast migration, enhancing fibroblast survival, and increasing the speed at which fibroblasts are able to reach a site of injury, BPC 157 increases rates of tissue repair by several orders of magnitude. All of this is achieved by simply stimulating natural healing processes. BPC 157 can best be thought of as boosting the function of the body's natural repair mechanisms.

Resources

[1] C.-H. Chang, W.-C. Tsai, M.-S. Lin, Y.-H. Hsu, and J.-H. S. Pang, "The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration," J. Appl. Physiol., vol. 110, no. 3, pp. 774-780, Mar. 2011.

[2] B. Bódis, O. Karádi, P. Németh, C. Dohoczky, M. Kolega, and G. Mózsik, "Evidence for direct cellular protective effect of PL-10 substances (synthesized parts of body protection compound, BPC) and their specificity to gastric mucosal cells," Life Sci., vol. 61, no. 16, p. PL 243-248, 1997.

What is BPC-157?

By Logan 7 months ago

BPC 157 is a partial form of the protein known as body protection compound (BPC). BPC is a natural component within the body and has been found, in experiments on animals, to promote healing. BPC is not just active in intestinal repair and healing, but appears to produce similar effects in a number of tissues. Scientific studies based on animal test subjects has shown that its healing actions are at least partially linked to growth hormone (GH).

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