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What is BPC-157?

“product By Logan 4 years ago

BPC 157 is a partial form of the protein known as body protection compound (BPC). BPC is a natural component within the body and has been found, in experiments on animals, to promote healing. BPC is not just active in intestinal repair and healing, but appears to produce similar effects in a number of tissues. Scientific studies based on animal test subjects has shown that its healing actions are at least partially linked to growth hormone (GH).

BPC-157 Research

It has been reported, in several different animal studies, that BPC 157 promotes healing in injuries ranging from inflammatory bowel disease to tendon and muscle transection [1]. A 2014 study in rats demonstrated that at least a part of the healing response results from increased GH receptor expression in the injured tissues subjected to BPC 157[2].

There are several growth factors involved in normal tissue healing. Examples include insulin-like growth factor, platelet-derived growth factor, transforming growth factor beta, and growth hormone. The roles that each factor plays vary based on the extent of the injury and the specific tissue that has sustained damage. GH, for example, is very active in repair of connective tissues like skeletal muscle, bone, cartilage, ligaments, and tendons. It has been found to increase the secretion of collagen, a protein that serves as the scaffolding for many connective tissues. By increasing the recruitment of GH to damaged tissue, BPC157 can increase the effects and speed recovery.

Fibroblasts and Genetic Modification

Previous animal test studies have showed that BPC-157 controls the functions of collagen fragments by promoting the work of fibroblasts, the cells responsible for collagen deposition and maintenance. More recent work on animal test subjects has revealed that BPC 157 influences fibroblasts by upregulating expression of the GH receptor gene. In other words BPC 157 alters the function of DNA.

Fibroblasts aren't just found in the intestine, but are active throughout the body. They are especially active in connective tissue. Administration of BPC-157 to injured connective tissue boosts the GH response by increasing GH receptor density. The result is that even with normal physiologic levels of GH, more is recruited to the site of injury and thus healing proceeds at a faster rate. Ongoing testing and research is revealing even more beneficial effects of BPC-157.

Resources

[1] T. Cerovecki, I. Bojanic, L. Brcic, B. Radic, I. Vukoja, S. Seiwerth, and P. Sikiric, "Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat," J. Orthop. Res. Off. Publ. Orthop. Res. Soc., vol. 28, no. 9, pp. 1155-1161, Sep. 2010.

[2] C.-H. Chang, W.-C. Tsai, Y.-H. Hsu, and J.-H. S. Pang, "Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts," Mol. Basel Switz., vol. 19, no. 11, pp. 19066-19077, 2014.

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