Swipe to the right

Peptide Sciences Blog

“product

Epithalon and Skin Rejuvenation

By Richard A. 9 months ago

Epithalon and Skin Rejuvenation

Skin rejuvenation is often associated with wrinkles and lines, but the truth runs deeper than wrinkles. Skin becomes more fragile and thus more prone to damage as it ages. Damage to the skin compromises its protective barrier function and can increase risk of infection. Research into ways to strengthen skin can not only make skin look younger, but can protect people from serious medical conditions. Thus far, most skin rejuvenation research has focused on collagen and other large skin proteins. New research, however, suggests that short peptide molecules, like epithalon, may hold more promise in preserving and even rejuvenating skin.

Epithalon Overview

Epithalon (a.k.a. epitalon), is a short (just four amino acids long) peptide that has been demonstrated to have anti-aging and anti-cancer properties in rodent studies. Because epithalon is so short, it can penetrate the cell membrane, without the aid of transporters, and make its way to the nucleus of cells. This is important because, once in the nucleus, epithalon can affect the regulation of genes, activating some and deactivating others to cause cell-wide changes1.

Previous research has indicated that epithalon can stimulate immune system function that has been lost due to natural aging. Investigation of the mechanism of this action uncovered the ability of the Ala-Glu-Asp-Gly peptide chain (Epithalon) to interact with the promoter region of the interferon gamma gene. By promoting the production of interferon gamma, a key immune regulator, epithalon is able to boost functioning in T-cells and thus overall immunity and well being1,2.

The idea that short peptides might be able to affect DNA-level processes has caused a boom in the investigation and research of epithalon and other short peptides in animal models. Those investigations have led to the understanding that epithalon can impact skin aging by activating cellular repair processes, which often go dormant as we age.

Epithalon Fights Aging by Activating Telomerase and More

By Logan E. 10 months ago

Epithalon Fights Aging by Activating Telomerase and More

Epithalon (epitalon) is a four-amino-acid-long peptide derived from a naturally occurring pineal gland protein. It has been shown, through extensive animal research, to be a potent regulator of cell metabolism, including growth and cell division. In particular, epithalon is able to extend cell survival in vitro. At least part of the reason that epithalon can extend cell survival comes down to its action on telomeres.

Telomeres

Telomeres, the repetitive nucleotide sequences at the end of linear chromosomes, protect DNA from degradation and deterioration. A telomere sequence starts out at about 11,000 DNA units (bases) long, but decreases in length to about 4,000 bases in old age. Interestingly, the rate of telomere degradation is faster in men than in women.

Telomeres are like self-sacrificing guards against actual DNA damage. Because they don’t code for anything, telomeres can be sacrificed when DNA is replicated (copied) without actually damaging any genes. This is necessary because DNA replication is an imperfect process. Of course, telomeres eventually get too short to serve their protective role. Cells have mechanisms to detect when this happens. When a telomere becomes too short, the cell either becomes inactive or dies. This is essentially the process of aging at a molecular level.

GHK-Cu Research

By Richard A. 10 months ago

GHK-Cu Research

GHK-Cu is a naturally occurring peptide, made of the three amino acids Glycine-Histidine-Lysine, that is complexed with a copper molecule. It was first isolated from human plasma (a part of blood), but can also be found in saliva and urine. It has been linked to skin and tissue healing as well as to immune function and antioxidant generation. Like many natural anti-aging compounds, tissue levels of GHK-Cu tend to drop as humans age, from a high of about 200 micrograms per milliliter at age 20 to a low of 80 micrograms per milliliter by age 601.

GHK-Cu and Skin Healing

About a decade ago, research studies revealed that GHK-Cu is involved in wound healing and in the regulation of scar formation. The list of processes that research has shown GHK-Cu to be involved in includes

  1. Attracting cells that are involved in the repair process,
  2. Suppressing free radicals,
  3. Reducing inflammation by boosting levels of key anti-inflammatory molecules,
  4. Increasing protein synthesis, and
  5. Increasing fibroblast growth and differentiation1.


Research from 2014 suggests that GHK-Cu may play an important role in regulating levels of transforming growth factor-β and insulin-like growth factor-2. By increasing levels of TGF-β and decreasing levels of IGF-2, GHK-Cu is able to improve skin healing while reducing the formation of hypertrophic scars2.

Controlled studies of GHK-Cu and aging skin in animals indicate that the peptide tightens skin, improves firmness, boosts elasticity, reduces fine lines and wrinkles, and helps to resolve photo damage. More recent research has also indicated that GHK-Cu can protect the liver from toxins, boost bone growth, and protect gastrointestinal tissue from ulcer formation. Now, it turns out, GHK-Cu also plays a role in protecting against microbial invaders.

Our Philosophy On Peptides

By Kenneth 10 months ago

Healthy living is an essential concern to all of us, and the drive to improve our well-being is as vital as it is universal. An invaluable part of this relentless pursuit is driven by clinical research involving growth hormone peptide compounds such as Growth Hormone Releasing Hexapeptide (GHRP-6) and Ipamorelin. That's why we at PeptideSciences.com are committed to offering only the highest quality peptides for research and laboratory applications. Our company maintains a vigorous passion for investigation and discovery shared by the thousands of researchers worldwide that have made us their exclusive peptide supplier. At PeptideSciences.com we're fervently engaged in the quest to uncover the exciting possibilities presented by the utilization of peptides in future therapeutic applications, and we're dedicated to doing our utmost to provide only the best quality Sermorelin and other peptides, such as Hexarelin, to researchers striving to unlock the potential of this extraordinary peptide.