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Peptide Sciences Blog

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IGF1 LR3 Information

By Carl 6 years ago

IGF1 LR3 (insulin-like growth factor-1 Long R3) is a non-glycosylated, recombinant polypeptide chain made up of 83 amino acids. IGF1 LR3 is the recombinant form of human IGF-1, and as such it contains the entire native amino acid sequence but with two major modifications: substitution of arginine (abbreviated R or arg) at position 3 with glutamic acid (abbreviated E or Glu) hence the label R3; and the extension of the N-terminus of the native sequence by a 13 amino-acid peptide hence the label long. The native form of a polypeptide refers to the naturally occurring amino acid sequence and the resultant conformational structure. The molecular weight of IGF1 LR3 as measured by Mass Spectrometry is 9.116 kD (kiloDaltons). A specifically designed protein expression system is utilized in the production of IGF1 LR3 in Escherichia Coli. Thereafter, chromatographic techniques are used to correctly fold and purify the IGF1 LR3 to the highly-active and functional IGF1 LR3 that can bind to human IGF-1R (insulin-like growth factor-1 receptor).

What is Thymosin Alpha-1

By Becka 6 years ago

Thymosin Alpha-1 is a biologically active peptide derived from prothymosin-alpha. Current hypotheses consider Thymosin Alpha-1 to be the main constituent of Thymosin Fraction-5, and as such it is considered to be the active component that restores the immune function in both athymic animals and animals with dysfunctional thymus glands. Thymosin Alpha-1 was among the first peptide isolates of Thymosin Fraction-5 to be sequenced and thereafter synthetically synthesized.

In humans, the PTMA gene encodes prothymosin-alpha, a 113 amino-acid polypeptide. Thymosin Alpha-1 is a 28 amino-acid fragment of prothymosin-alpha, and research has shown that this fragment derivative enhances the cell-mediated immune component of the human immune system. Its immune actions have enabled it to be used for treating viral infections such as Hepatitis B and Hepatitis C. It has also been incorporated into vaccines as an immune booster. Clinical studies have also shown that Thymosin Alpha-1 can be used to manage neoplasias since they upregulate cytotoxic T-cells which are involved in immune surveillance.

What is Adipotide?

By Carl 6 years ago

Adipotide is a peptidomimetic compound that has been shown to possess pro-apoptotic properties that do cause weight loss in rhesus monkeys and mice. Its sequence is CKGGRAKDC-GG-D(KLAKLAK)2. Studies have shown that its mode of action involves the selective apoptosis of blood vessels supplying the white adipose tissue. Adipotide causes such vessels to undergo atrophy (shrinkage) and eventually apoptosis (cell death), thus cutting off the blood supply to the fat cells. This results in ischemic injury, which is a lack of blood supply and oxygen to the fat cells. The effects are non-reversible, so the fat cells also undergo apoptosis or cell death.

What is Epithalon?

By Rick 6 years ago

Epithalon is currently being studied and researched by Scientists and Doctors specializing in the field of anti-aging care and medicine. EPITHALON (Epitalon) is one of the most important breakthroughs in the study of anti-aging.

The Epithalon (Epitalon) tetrapeptide has been discovered by researchers in Russia. This was seen to reactivate the production of cell telomerase thus slowing down the aging process and rejuvenating the entire body. The development of molecular biology required bio-chemical studies that were nothing short of profound. Scientific work by Gobind Khorana and Marshall Nirenberg for many years resulted in defining codons or nucleotides and triplets and the genetic code of each of the 20 amino acids. This resulted in a Nobel Prize award in 1968 with Robert Holley. Nucleic acid investigations and identification of DNA and RNA base sequences were also conducted by the 1980 Nobel Prize winner for Chemistry Frederick Sanger along with Walter Gilbert and Paul Berg. These studies revealed the cause of aging.